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The efficacy of semaglutide injections hinges on the careful selection of the injection site. Preferred locations for subcutaneous injections include the stomach, thigh, or the back of the upper arm. Each of these regions provides an ideal subcutaneous fat layer, facilitating optimal absorption of the medication.  

Stomach: The stomach is a commonly recommended injection site due to its large surface area and relatively easy accessibility. The subcutaneous fat layer in this region allows for efficient absorption of semaglutide. When injecting a semaglutide in the stomach pick a spot approximately two inches from the belly button. 

Thigh: The thigh is another popular choice as it also has a sufficient fat layer, making it suitable for subcutaneous injections. Choose an area on the front of the thigh and avoid the inner thigh. 

Upper arm: The back of the upper arm is another option, particularly for individuals who prefer injecting in a less visible area. For upper arm injections, choose an injection site between the shoulder and elbow. 

1. Prepare the injection – gather the necessary supplies, wash hands, check the medication for any abnormalities. The liquid in the pen should be clear and colorless. Do not use it if it is cloudy, discolored, or has particles in it. 
2. Select the injection site in either the stomach, thigh, or upper arm. 
3. Clean the area – use an alcohol swap to clean the chosen injection site. 
4. Injecting the medication – hold the syringe at a 45-degree angle to the skin, insert a new needle swiftly and steadily, inject the medication and hold for a few seconds before you remove the needle. 
5. Dispose of supplies – safely dispose of the used needle and any other materials. Throw away used needles in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets. 

The frequency of rotating injection sites for semaglutide can depend on the recommendations provided by your healthcare professional or prescribing information for the medication. However, as a general guideline, it is advised to use a different body area each time you give yourself a shot. 

For example, if you are administering semaglutide once a week, you might rotate between the stomach, thigh, and upper arm. This rotation helps prevent irritation, discomfort, or changes in the skin at the injection site. 

Keep track of where you give each injection to make sure you rotate body areas.